High Throughput Screening

Solazyme employs proprietary high-throughput screening methods for quickly and cost-effectively screening large libraries of strain variants to develop optimized production strains. Automating the process speeds up the optimization of strains and guarantees high quality results. The process can be applied to a multitude of optimization problems and comprises a number of key components:

• Organism Libraries: Solazyme possesses a large and growing library of microorganisms.
• Genetic libraries: DNA libraries are generated synthetically and from isolated organisms. Solazyme continues to develop a growing and diverse collection of ready-to-screen DNA libraries.
• Genomics: Promising targets are identified by bioinformatic analysis of both public and proprietary genomic data.
• Targeted Assay Technologies: Proprietary assay technologies are vital to developing the best production strains. Sensitive and application-specific assays are applied to bioproduction targets. These highly selective assays are used to identify novel microorganisms displaying desired phenotypes.

The company's integrated screening methods and parallel library creation effectively capitalize on the large amounts of information generated through the screening process.